 Institut Dr. Schrader CREACHEM GmbH | |
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Ozone test chamber
Dissolution Tester
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Toxicology
 In Vitro Efficacy Testing
Institut Dr. Schrader Creachem GmbH
Cell culture tests and studies in human tissue models are cost-effective ways to screen new active substances for their possible effects as a pre-selection can be made before expensive, time-consuming studies are performed on volunteers to substantiate the test results.
Depending on the expected effect, different test systems ranging from simple tentative experiments in a test tube to complicated tests in 3-D skin models are used to assess the efficacy. When we develop new in vitro tests to prove the efficacy of cosmetics and pharmaceuticals we concentrate on forward-looking solutions that go beyond the horizon of routine tests. Please feel free to contact us for more detailed information.
Our range of services includes the following tests:
- Determination of antioxidant properties in the carbonyl protein assay (protein oxidation), deoxyribose test (hydrocarbon oxidation), linoleic acid test (lipid oxidation) and COMET assay (DNA oxidation)
- Evaluation of wound healing stimulation properties: determination of cell proliferation (MTT assay, NRU assay, BrdU assay) und Sandwich ELISA assays (e.g. IL-6, MMP-1, MMP-9, KGF etc.) in cell cultures and human skin models
- Assessment of anti-inflammatory / curative properties in cell cultures and human skin models by means of Sandwich ELISA for IL-1α, IL-6, IL-18, PGE-2 and TNFα
- CAM assay, determination of the anti-angiogenetic properties of new active substances in hen's eggs
- Tube formation assay in HUVEC cells for classification of a possible anti-angiogenetic effect
- Dissolution testing, e.g. according to pharmacopeias for ointments, tablets, fabrics, etc.
Tube Formation Assay
Untreated control
Weak anti-angiogenetic effect
Strong anti-angiogenetic effect
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